Biopsies of olfactory epithelium in patients with Parkinson's disease
Identifieur interne : 002427 ( Main/Exploration ); précédent : 002426; suivant : 002428Biopsies of olfactory epithelium in patients with Parkinson's disease
Auteurs : Martin Witt [Allemagne] ; Katja Bormann [Allemagne] ; Volker Gudziol [Allemagne] ; Kerstin Pehlke [Allemagne] ; Kathrin Barth [Allemagne] ; Amir Minovi [Allemagne] ; Antje H Hner [Allemagne] ; Heinz Reichmann [Allemagne] ; Thomas Hummel [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-04-30.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Anosmia, Biopsy, Biopsy (methods), Female, Forkhead Transcription Factors (metabolism), Human, Humans, Immunohistochemistry, Ki-67 Antigen (metabolism), Male, Middle Aged, Nerve Tissue Proteins (metabolism), Nervous system diseases, Olfaction Disorders (etiology), Olfaction Disorders (metabolism), Olfaction Disorders (pathology), Olfactory Marker Protein (genetics), Olfactory Marker Protein (metabolism), Olfactory Mucosa (metabolism), Olfactory Mucosa (pathology), Olfactory disorder, Olfactory epithelium, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson disease, RT‐PCR, Receptors, Nerve Growth Factor (metabolism), Reverse transcription polymerase chain reaction, Ubiquitin Thiolesterase (metabolism), Young Adult, anosmia, hyposmia, immunohistochemistry, olfactory epithelium, smell.
- MESH :
- chemical , genetics : Olfactory Marker Protein.
- chemical , metabolism : Forkhead Transcription Factors, Ki-67 Antigen, Nerve Tissue Proteins, Olfactory Marker Protein, Receptors, Nerve Growth Factor, Ubiquitin Thiolesterase.
- complications : Parkinson Disease.
- etiology : Olfaction Disorders.
- metabolism : Olfaction Disorders, Olfactory Mucosa.
- methods : Biopsy.
- pathology : Olfaction Disorders, Olfactory Mucosa, Parkinson Disease.
- Adult, Age Factors, Aged, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder involving several neuronal systems. Impaired olfactory function may constitute one of the earliest symptoms of PD. However, it is still unclear to what degree changes of the olfactory epithelium may contribute to dysosmia and if these changes are different from those of other hyposmic or anosmic patients. This study aimed to investigate the hypothesis that olfactory loss in PD is a consequence of specific PD‐related damage of olfactory epithelium. Biopsies of 7 patients diagnosed with PD were taken. Six patients with PD were hyposmic, one anosmic. As non‐PD controls served 9 patients with hyposmia, 9 with anosmia, and 7 normosmic individuals. Further, nasal mucosa of 4 postmortem individuals was investigated. Immunohistochemical examinations were performed with antibodies against olfactory marker protein (OMP), protein gene product 9.5 (PGP 9.5), beta‐tubulin, (BT), proliferation‐associated antigen (Ki 67), the stem cell marker nestin, cytokeratin, p75NGFr, and α‐synuclein. Most of the biopsy specimens exhibited irregular areas of olfactory‐like, dysplastic epithelium positive for either PGP 9.5 or BT, but negative for OMP. No major histochemical differences in either the expression or distribution of these proteins were observed in the olfactory epithelium of patients with PD compared with controls. Reverse transcription PCR (RT‐PCR) data indicated mRNA for OMP in almost all subjects, independently of their olfactory performance. These data support the idea that olfactory loss in Parkinson's disease is not a consequence of damage to the olfactory epithelium but rather results from distinct central‐nervous abnormalities. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22464
Affiliations:
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nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Dresden Medical School, 01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Dresden Medical School, 01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Hummel, Thomas" sort="Hummel, Thomas" uniqKey="Hummel T" first="Thomas" last="Hummel">Thomas Hummel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Otorhinolaryngology, Interdisciplinary Center for Smell and Taste, University of Dresden Medical School, 01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-04-30">2009-04-30</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="906">906</biblScope><biblScope unit="page" to="914">914</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">0744835A9C2F9F6258CD0268AD01409B7A6B4805</idno><idno type="DOI">10.1002/mds.22464</idno><idno type="ArticleID">MDS22464</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Anosmia</term><term>Biopsy</term><term>Biopsy (methods)</term><term>Female</term><term>Forkhead Transcription Factors (metabolism)</term><term>Human</term><term>Humans</term><term>Immunohistochemistry</term><term>Ki-67 Antigen (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Nerve Tissue Proteins (metabolism)</term><term>Nervous system diseases</term><term>Olfaction Disorders (etiology)</term><term>Olfaction Disorders (metabolism)</term><term>Olfaction Disorders (pathology)</term><term>Olfactory Marker Protein (genetics)</term><term>Olfactory Marker Protein (metabolism)</term><term>Olfactory Mucosa (metabolism)</term><term>Olfactory Mucosa (pathology)</term><term>Olfactory disorder</term><term>Olfactory epithelium</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Parkinson disease</term><term>RT‐PCR</term><term>Receptors, Nerve Growth Factor (metabolism)</term><term>Reverse transcription polymerase chain reaction</term><term>Ubiquitin Thiolesterase (metabolism)</term><term>Young Adult</term><term>anosmia</term><term>hyposmia</term><term>immunohistochemistry</term><term>olfactory epithelium</term><term>smell</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Olfactory Marker Protein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Forkhead Transcription Factors</term><term>Ki-67 Antigen</term><term>Nerve Tissue Proteins</term><term>Olfactory Marker Protein</term><term>Receptors, Nerve Growth Factor</term><term>Ubiquitin Thiolesterase</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Olfaction Disorders</term><term>Olfactory Mucosa</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biopsy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Olfaction Disorders</term><term>Olfactory Mucosa</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anosmie</term><term>Biopsie</term><term>Epithélium olfactif</term><term>Homme</term><term>Immunohistochimie</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Réaction chaîne polymérase RT</term><term>Trouble de l'odorat</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a neurodegenerative disorder involving several neuronal systems. Impaired olfactory function may constitute one of the earliest symptoms of PD. However, it is still unclear to what degree changes of the olfactory epithelium may contribute to dysosmia and if these changes are different from those of other hyposmic or anosmic patients. This study aimed to investigate the hypothesis that olfactory loss in PD is a consequence of specific PD‐related damage of olfactory epithelium. Biopsies of 7 patients diagnosed with PD were taken. Six patients with PD were hyposmic, one anosmic. As non‐PD controls served 9 patients with hyposmia, 9 with anosmia, and 7 normosmic individuals. Further, nasal mucosa of 4 postmortem individuals was investigated. Immunohistochemical examinations were performed with antibodies against olfactory marker protein (OMP), protein gene product 9.5 (PGP 9.5), beta‐tubulin, (BT), proliferation‐associated antigen (Ki 67), the stem cell marker nestin, cytokeratin, p75NGFr, and α‐synuclein. Most of the biopsy specimens exhibited irregular areas of olfactory‐like, dysplastic epithelium positive for either PGP 9.5 or BT, but negative for OMP. No major histochemical differences in either the expression or distribution of these proteins were observed in the olfactory epithelium of patients with PD compared with controls. Reverse transcription PCR (RT‐PCR) data indicated mRNA for OMP in almost all subjects, independently of their olfactory performance. These data support the idea that olfactory loss in Parkinson's disease is not a consequence of damage to the olfactory epithelium but rather results from distinct central‐nervous abnormalities. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Dresde</li><li>Saxe (Land)</li></region><settlement><li>Dresde</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Witt, Martin" sort="Witt, Martin" uniqKey="Witt M" first="Martin" last="Witt">Martin Witt</name></noRegion><name sortKey="Barth, Kathrin" sort="Barth, Kathrin" uniqKey="Barth K" first="Kathrin" last="Barth">Kathrin Barth</name><name sortKey="Bormann, Katja" sort="Bormann, Katja" uniqKey="Bormann K" first="Katja" last="Bormann">Katja Bormann</name><name sortKey="Gudziol, Volker" sort="Gudziol, Volker" uniqKey="Gudziol V" first="Volker" last="Gudziol">Volker Gudziol</name><name sortKey="H Hner, Antje" sort="H Hner, Antje" uniqKey="H Hner A" first="Antje" last="H Hner">Antje H Hner</name><name sortKey="H Hner, Antje" sort="H Hner, Antje" uniqKey="H Hner A" first="Antje" last="H Hner">Antje H Hner</name><name sortKey="Hummel, Thomas" sort="Hummel, Thomas" uniqKey="Hummel T" first="Thomas" last="Hummel">Thomas Hummel</name><name sortKey="Minovi, Amir" sort="Minovi, Amir" uniqKey="Minovi A" first="Amir" last="Minovi">Amir Minovi</name><name sortKey="Pehlke, Kerstin" sort="Pehlke, Kerstin" uniqKey="Pehlke K" first="Kerstin" last="Pehlke">Kerstin Pehlke</name><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name><name sortKey="Witt, Martin" sort="Witt, Martin" uniqKey="Witt M" first="Martin" last="Witt">Martin Witt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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